Conserved noncoding sequences highlight shared components of regulatory networks in dicotyledonous plants

Conserved noncoding sequences (CNSs) in DNA are reliable pointers to regulatory elements controlling gene expression. Using a comparative genomics approach with four dicotyledonous plant species (Arabidopsis thaliana, papaya [Carica papaya], poplar [Populus trichocarpa], and grape [Vitis vinifera]), we detected hundreds of CNSs upstream of Arabidopsis genes. Distinct positioning, length, and enrichment for transcription factor binding sites suggest these CNSs play a functional role in transcriptional regulation. The enrichment of transcription factors within the set of genes associated with CNS is consistent with the hypothesis that together they form part of a conserved transcriptional network whose function is to regulate other transcription factors and control development. We identified a set of promoters where regulatory mechanisms are likely to be shared between the model organism Arabidopsis and other dicots, providing areas of focus for further research

Predicting Non-linear Cellular Automata Quickly by Decomposing Them into Linear Ones

We show that a wide variety of non-linear cellular automata (CAs) can be decomposed into a quasidirect product of linear ones. These CAs can be predicted by parallel circuits of depth O(log^2 t) using gates with binary inputs, or O(log t) depth if ``sum mod p'' gates with an unbounded number of inputs are allowed. Thus these CAs can be predicted by (idealized) parallel computers much faster than by explicit simulation, even though they are non-linear. This class includes any CA whose rule, when written as an algebra, is a solvable group. We also show that CAs based on nilpotent groups can be predicted in depth O(log t) or O(1) by circuits with binary or ``sum mod p'' gates respectively. We use these techniques to give an efficient algorithm for a CA rule which, like elementary CA rule 18, has diffusing defects that annihilate in pairs. This can be used to predict the motion of defects in rule 18 in O(log^2 t) parallel time

Military elites and the study of war

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67081/2/10.1177_002200275700100103.pd

Swings and roundabouts: the vagaries of democratic consolidation and ‘electoral rituals’ in Sierra Leone

YesThe history of the electoral process in Sierra Leone is at the same time tortuous and substantial. From relatively open competitive multi-party politics in the 1960s, which led to the first turnover of power at the ballot box, through the de facto and de jure one-party era, which nonetheless had elements of electoral competition, and finally to contemporary post-conflict times, which has seen three elections and a second electoral turnover in 2007, one can discern evolving patterns. Evidence from the latest local and national elections in 2012 suggests that there is some democratic consolidation, at least in an electoral sense. However, one might also see simultaneous steps forward and backward – What you gain on the swings, you may lose on the roundabouts. This is particularly so in terms of institutional capacities, fraud and violence, and one would need to enquire of the precise ingredients – in terms of political culture or in other words the attitudes and motivations of electors and the elected – of this evolving Sierra Leonean, rather than specifically liberal type, of democracy. Equally, the development of ‘electoral rituals’, whether peculiar to Sierra Leone or not and whether deemed consolidatory or not, has something to say as part of an investigation into the electoral element of democratic consolidation.1 The literature on elections in Africa most often depicts a number of broad features, such as patronage, ethno-regionalism, fraud and violence, and it is the intention of this article to locate contemporary Sierra Leone, as precisely as possible, within the various strands of this discourse

Gastric function in Caiman crocodilus (Crocodylia: Reptilia)--II. Effects of temperature on pH and proteolysis

1. 1. In Caiman crocodilus, the pH of the gastric secretions during digestion may reach 1[middle dot]2 in specimens kept between 20 and 30[deg]C. C. crocodilus feeds and digests at 15[deg]C, but the pH of gastric secretions did not drop below 1[middle dot]8.2. 2. The gastric secretion increased in rate and hydrochloric acid concentration after injections of histamine (400 [mu]g/kg body weight, given in four hourly doses). The rate increased from 0[middle dot]05 ml/kg.hr (resting rate, at 20[deg]C) up to an average of 0[middle dot]66 ml/kg.hr, at 30[deg]C.3. 3. There is a latent period of 4-8 hr before the effects of histamine can be detected in tests carried out at 20, 25 and 30[deg]C.4. 4. Peptic proteolysis of gastric secretions has pH optima in the range 2[middle dot]0-2[middle dot]6, when carried out at 25[deg]C, using the hemoglobin method of Anson & Mirsky.5. 5. There were instances of more than one pH optimum for proteolysis, suggesting the occurrence of isozymes.6. 6. Inside the range in which C. crocodilus feeds and digests, peptic proteolysis has an average Q10 of 1[middle dot]62 (between 15 and 25[deg]C) and of 1[middle dot]50 (between 25 and 35[deg]C).7. 7. In animals maintained at 25[deg]C peptic proteolysis was highest at 24-48 hr after feeding.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22044/1/0000462.pd

Investigation of initiation of gigantic jets connecting thunderclouds to the ionosphere

The initiation of giant electrical discharges called as "gigantic jets" connecting thunderclouds to the ionosphere is investigated by numerical simulation method in this paper. Using similarity relations, the triggering conditions of streamer formation in laboratory situations are extended to form a criterion of initiation of gigantic jets. The energy source causing a gigantic jet is considered due to the quasi-electrostatic field generated by thunderclouds. The electron dynamics from ionization threshold to streamer initiation are simulated by the Monte Carlo technique. It is found that gigantic jets are initiated at a height of ~18-24 km. This is in agreement with the observations. The method presented in this paper could be also applied to the analysis of the initiation of other discharges such as blue jets and red sprites.Comment: 12th International Congress on Plasma Physics, 25-29 October 2004, Nice (France

Learning Combinations of Multiple Feature Representations for Music Emotion Prediction

Music consists of several structures and patterns evolving through time which greatly influences the human decoding of higher-level cognitive aspects of music like the emotions expressed in music. For tasks, such as genre, tag and emotion recognition, these structures have often been identified and used as individual and non-temporal features and representations. In this work, we address the hypothesis whether using multiple temporal and non-temporal representations of different features is beneficial for modeling music structure with the aim to predict the emotions expressed in music. We test this hypothesis by representing temporal and non-temporal structures using generative models of multiple audio features. The representations are used in a discriminative setting via the Product Probability Kernel and the Gaussian Process model enabling Multiple Kernel Learning, finding optimized combinations of both features and temporal/ non-temporal representations. We show the increased predictive performance using the combination of different features and representations along with the great interpretive prospects of this approach

Democracy, development and the executive presidency in Sri Lanka

This paper examines the developmental causes and consequences of the shift from a parliamentary to a semi-presidential system in Sri Lanka in 1978, examining its provenance, rationale, and its unfolding trajectory. drawing on a wide range of sources, it set out an argument that the executive presidency was born out of an elite impulse to create a more stable, centralised political structure to resist the welfarist electoral pressures that had taken hold in the post-independence period, and to pursue a market-driven model of economic growth. This strategy succeeded in its early years 197801993, when presidents retained legislative control, maintained a strong personal commitment to market reforms, and cultivated alternative sources of legitimacy. In the absence of these factors, the presidency slipped into crisis over 1994-2004 as resistance to elite-led projects of state reform mounted and as the president lost control of the legislature. Since 2005 the presidency has regained its power, but at the cost of abandoning its original rationale and function as a means to recalibrate the elite/mass power relations to facilitate elite-led reform agendas